AACR Project Genomics Evidence Neoplasia Information Exchange (GENIE) (USA)

Database Contact Data

Shawn M. Sweeney, PhD
Director, AACR Project GENIE Coordinating Center
Executive Office
American Association for Cancer Research
615 Chestnut Street, 17th Floor
Philadelphia, PA 19106-4404
USA
Phone: +1 215-446-7148 (Direct) 
Fax: +1 267-765-1043
Email: shawn.sweeney@aacr.org

Alternate Contact

AMERICAN ASSOCIATION FOR CANCER RESEARCH
615 Chestnut St., 17th Floor
Philadelphia, PA 19106-4404
USA
Phone: +1 215-440-9300
Email: aacr@aacr.org

References of Studies Using/Describing Database

1. Choudhury NJ, Lavery JA, Brown S, de Bruijn I, Jee J, Tran TN, Rizvi H, Arbour KC, Whiting K, Shen R, Hellmann M. The GENIE BPC NSCLC cohort: a real-world repository integrating standardized clinical and genomic data for 1,846 patients with non-small cell lung cancer. Clinical Cancer Research. 2023 May 24:CCR-23.

2. Lavery JA, Brown S, Curry MA, Martin A, Sjoberg DD, Whiting K. A data processing pipeline for the AACR project GENIE biopharma collaborative data with the {genieBPC} R package. Bioinformatics. 2023 Jan;39(1):btac796.

3. Scharpf RB, Balan A, Ricciuti B, Fiksel J, Cherry C, Wang C, Lenoue-Newton ML, Rizvi HA, White JR, Baras AS, Anaya J. Genomic Landscapes and Hallmarks of Mutant RAS in Human Cancers. Cancer research. 2022 Nov 2;82(21):4058-78.

4. LeNoue-Newton ML, Chen SC, Stricker T, Hyman DM, Blauvelt N, Bedard PL, Meric-Bernstam F, Punglia RS, Schrag D, Lepisto EM, Andre F. Natural history and characteristics of ERBB2-mutated hormone receptor–positive metastatic breast cancer: a multi-institutional retrospective case–control study from AACR project GENIE. Clinical Cancer Research. 2022 May 13;28(10):2118-30.

5. Brown S, Lavery JA, Shen R, Martin AS, Kehl KL, Sweeney SM, Lepisto EM, Rizvi H, McCarthy CG, Schultz N, Warner JL, Park BH, Bedard PL, Riely GJ, Schrag D, Panageas KS; AACR Project GENIE Consortium. Implications of Selection Bias Due to Delayed Study Entry in Clinical Genomic Studies. JAMA Oncol. 2022 Feb 1;8(2):287-291.

6. Lavery JA, Lepisto EM, Brown S, Rizvi H, McCarthy C, LeNoue-Newton M, Yu C, Lee J, Guo X, Yu T, Rudolph J, Sweeney S; AACR Project GENIE Consortium, Park BH, Warner JL, Bedard PL, Riely G, Schrag D, Panageas KS. A Scalable Quality Assurance Process for Curating Oncology Electronic Health Records: The Project GENIE Biopharma Collaborative Approach. JCO Clin Cancer Inform. 2022 Feb;6:e2100105.

7. Kehl KL, Riely GJ, Lepisto EM, Lavery JA, Warner JL, LeNoue-Newton ML, Sweeney SM, Rudolph JE, Brown S, Yu C, Bedard PL, Schrag D, Panageas KS; American Association of Cancer Research (AACR) Project Genomics Evidence Neoplasia Information Exchange (GENIE) Consortium. Correlation Between Surrogate End Points and Overall Survival in a Multi-institutional Clinicogenomic Cohort of Patients With Non-Small Cell Lung or Colorectal Cancer. JAMA Netw Open. 2021 Jul 1;4(7):e2117547.

8. Takayanagi D, Hirose S, Kuno I, Asami Y, Murakami N, Matsuda M, Shimada Y, Sunami K, Komatsu M, Hamamoto R, Kato MK, Matsumoto K, Kohno T, Kato T, Shiraishi K, Yoshida H. Comparative Analysis of Genetic Alterations, HPV-Status, and PD-L1 Expression in Neuroendocrine Carcinomas of the Cervix. Cancers (Basel). 2021 Mar 10;13(6):1215.

9. Zhao Y, Yu H, Ida CM, Halling KC, Kipp BR, Geiersbach K, Rumilla KM, Gupta S, Lin MT, Zheng G. Assessment of RAS Dependency for BRAF Alterations Using Cancer Genomic Databases. JAMA Netw Open. 2021 Jan 4;4(1):e2035479.

10. Holowatyj AN, Eng C, Wen W, Idrees K, Guo X. Spectrum of Somatic Cancer Gene Variations Among Adults With Appendiceal Cancer by Age at Disease Onset. JAMA Netw Open. 2020 Dec 1;3(12):e2028644.

Vinay Mehta, PhD, MS

B.R.I.D.G.E TO DATA (BTD) is the prevailing resource for capturing detailed global metadata on real-world databases.  The developers of BTD have spent meticulous thought into creating a process for collecting (and maintaining) data by building relationships with key data vendors across the world.  With the breadth and magnitude of global real-world data available, it’s a testament to the scientific staff at BTD to successfully achieve such an ambitious undertaking.

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