Aug 26, 2025: Our first registry dedicated to severe asthma has been added

With data starting in 2017, the International Severe Asthma Registry (ISAR) is the first global registry for severe asthma, created as a joint initiative where national registries retain ownership of their data while sharing it with ISAR for ethically approved research. By collecting anonymized, standardized patient-level data from around the world, ISAR provides a unique, longitudinal and real-life resource to study severe asthma.

International Severe Asthma Registry (ISAR) (United Kingdom)

Database Contact Data

5 Coles Lane Oakington
Cambridgeshire CB24 3BA
UNITED KINGDOM
Email: isar@optimumpatientcare.org
Phone: +44 123 967855

Alternate Contact

SINGAPORE office:
Phone : +65 3105 1489
Email: isar@optimumpatientcare.org

You may also complete the Contact Us form at https://www.isar.opcglobal.org/contact-us

References of Studies Using/Describing Database

1. Schleich F, Larenas-Linnemann D, Altraja A, de Llano LP, Kostikas K, Sadatsafavi M, Bourdin A, Pleasants RA, Hew M, Chen W, Jiménez-Maldonado L. Biomarker profile and disease burden associated with intermittent and long-term oral corticosteroid use in patients with severe asthma prior to biologic initiation in real-life (STAR). World Allergy Organization Journal. 2025 Jul 1;18(7):101066.

2. Côté A, Beaulé R, Boulay MÈ, Guertin J, Boulet LP, Godbout K, Price D. Poor Agreement Among Asthma Specialists on the Choice and Timing of Initiation of a Biologic Treatment for Severe Asthma Patients. J Allergy Clin Immunol Pract. 2025 Jun;13(6):1358-1366.e9.

3. Sadatsafavi M, Tran TN, Scelo G, Tsai MJ, Busby J, Emmanuel B, Heaney LG, Jenkins C, Hoyte F, Canonica GW, Katial R, Heffler E, Wang E, Puggioni F, Wechsler ME, Ardusso LRF, Máspero J, Sivori M, Emmas C, Menzies-Gow AN, Stjepanovic N, Bosnic-Anticevich SZ, Cochrane B, Denton E, Gibson PG, Hew M, Middleton PG, Peters MJ, Brusselle GG, Louis R, Schleich F, Christoff GC, Popov TA, Bergeron C, Bhutani M, Chapman KR, Côté A, Couillard S, Dorscheid DR, Jiménez-Maldonado L, Solarte I, Torres-Duque CA, Hansen S, Porsbjerg CM, Ulrik CS, Altraja A, Bourdin A, Exarchos KP, Gogali A, Kostikas K, Makris MP, Papaioannou AI, Mitchell PD, Iwanaga T, Nagano T, Tohda Y, Al-Ahmad MS, Larenas-Linnemann D, Aarli BB, Kuna P, Chaves Loureiro C, Al-Lehebi R, Bulkhi AA, Chen W, Juang YR, Koh MS, Liu A, Rhee CK, Cosio BG, Perez-de-Llano L, Perng DW, Sheu CC, Wang HC, Mahboub B, Salameh L, Jackson DJ, Patel PH, Pfeffer PE, Lugogo N, Pleasants RA, Beastall A, Bulathsinhala L, Carter V, Eleangovan N, Fletton K, Townend J, Murray RB, Price DB. Prevention of Cardiovascular and Other Systemic Adverse Outcomes in Patients with Asthma Treated with Biologics. Am J Respir Crit Care Med. 2025 May 18. Epub ahead of print.

4. Chen W, Tran TN, Townend J, Christoff GC, Tsai MJ, Altraja A, Cochrane B, Cosio BG, Sivori M, Murray RB, Makris MP, Scelo G, Bulathsinhala L, Ardusso LRF, Franchi ME, Máspero J, Saldarini F, Stok AM, Tomaszuk AG, Yañez A, Emmanuel B, Emmas C, Kostikas K, Menzies-Gow AN, Stjepanovic N, Bosnic-Anticevich SZ, Denton E, Gibson PG, Hew M, Jenkins C, Middleton PG, Peters MJ, Upham JW, Brusselle GG, Louis R, Schleich F, Pitrez PM, Popov TA, Bergeron C, Bhutani M, Chapman KR, Côté A, Couillard S, Dorscheid DR, Lougheed MD, Sadatsafavi M, Celis-Preciado CA, Jiménez-Maldonado L, Rodríguez-Cáceres B, Cano Rosales DJ, Solarte I, Torres-Duque CA, Hansen S, Porsbjerg CM, Ulrik CS, Bourdin A, Bakakos P, Exarchos KP, Gogali A, Ladias AA, Papadopoulos NG, Papaioannou AI, Costello RW, Cushen B, Mitchell PD, Canonica GW, Heffler E, Puggioni F, Iwanaga T, Nagano T, Tohda Y, Al-Ahmad MS, Larenas-Linnemann D, Aarli BB, Lehmann S, Kuna P, Ferreira JA, Fonseca JA, Loureiro CC, Al-Lehebi R, Bulkhi AA, Juang YR, Koh MS, Liu A, Rhee CK, Perez-de-Llano L, Fu PK, Perng DW, Sheu CC, Wang HC, Mahboub B, Salameh L, Busby J, Heaney LG, Jackson DJ, Patel PH, Pfeffer PE, Hoyte F, Katial RK, Lugogo N, Pleasants RA, Wang E, Wechsler ME, Beastall A, Carter V, Eleangovan N, Fletton K, Price DB; ISAR SOLAR I Working Group. Impact of Biologics Initiation on Oral Corticosteroid Use in the International Severe Asthma Registry and the Optimum Patient Care Research Database: A Pooled Analysis of Real-World Data. J Allergy Clin Immunol Pract. 2025 Apr 26:S2213-2198(25)00390-3. doi: 10.1016/j.jaip.2025.04.032. Epub ahead of print.

5. Larenas-Linnemann D, Rhee CK, Altraja A, Busby J, Tran TN, Wang E, Popov TA, Mitchell PD, Pfeffer PE, Pleasants RA, Katial R, Koh MS, Bourdin A, Schleich F, Máspero J, Hew M, Peters MJ, Jackson DJ, Christoff GC, Perez-de-Llano L, Cherrez-Ojeda I, Fonseca JA, Costello RW, Torres-Duque CA, Kuna P, Menzies-Gow AN, Stjepanovic N, Gibson PG, Pitrez PM, Bergeron C, Porsbjerg CM, Taillé C, Taube C, Papadopoulos NG, Papaioannou AI, Salvi S, Canonica GW, Heffler E, Iwanaga T, Al-Ahmad MS, Lehmann S, Al-Lehebi R, Cosio BG, Perng DW, Mahboub B, Heaney LG, Patel PH, Lugogo N, Wechsler ME, Bulathsinhala L, Carter V, Fletton K, Neil DL, Scelo G, Price DB. International Severe Asthma Registry (ISAR): 2017-2024 Status and Progress Update. Tuberc Respir Dis (Seoul). 2025 Apr;88(2):193-215.

6. Tran TN, Chen S, Emmanuel B, Altraja A, Bourdin A, Sheu CC, Tsai MJ, Hoyte FCL, Quinton A, Cook B, Bulathsinhala L, Henley W, Goh CYY, Liu Y, Ariti C, Carter V, Price DB; CLEAR Study Working Group. Real-World Biologic Use Patterns in Severe Asthma, 2015-2021: The CLEAR Study. Pragmat Obs Res. 2025 Mar 18;16:51-66.

7. Le TT, Price DB, Erhard C, Cook B, Quinton A, Katial R, Christoff GC, Perez-de-Llano L, Altraja A, Bergeron C, Bourdin A. Disease burden and access to biologic therapy in patients with severe asthma, 2017–2022: an analysis of the international severe asthma registry. Journal of Asthma and Allergy. 2024 Dec 31:1055-69.

8. Perez-de-Llano L, Scelo G, Tran TN, Le TT, Fagerås M, Cosio BG, Peters M, Pfeffer PE, Al-Ahmad M, Al-Lehebi RO, Altraja A, Bergeron C, Bjermer LH, Bjerrum AS, Bulathsinhala L, Busby J, Cano Rosales DJ, Canonica GW, Carter VA, Charriot J, Christoff GC, Denton EJ, Dorscheid DR, Fernandez Sanchez MJ, Fonseca JA, Gibson PG, Goh CYY, Heaney LG, Heffler E, Hew M, Iwanaga T, Katial R, Koh MS, Kuna P, Larenas-Linnemann DES, Lehtimäki L, Mahboub B, Martin N, Matsumoto H, Menzies-Gow AN, Papadopoulos NG, Popov TA, Porsbjerg CM, Patel P, Rhee CK, Sadatsafavi M, Taillé C, Torres-Duque CA, Tsai MJ, Ulrik CS, Upham JW, von Bülow A, Wang E, Wechsler ME, Price DB. Exploring Definitions and Predictors of Severe Asthma Clinical Remission after Biologic Treatment in Adults. Am J Respir Crit Care Med. 2024 Oct 1;210(7):869-880.

9. Denton E, Hew M, Peters MJ, Upham JW, Bulathsinhala L, Tran TN, Martin N, Bergeron C, Al-Ahmad M, Altraja A, Larenas-Linnemann D, Murray R, Celis-Preciado CA, Al-Lehebi R, Belhassen M, Bhutani M, Bosnic-Anticevich SZ, Bourdin A, Brusselle GG, Busby J, Canonica GW, Heffler E, Chapman KR, Charriot J, Christoff GC, Chung LP, Cosio BG, Côté A, Costello RW, Cushen B, Fingleton J, Fonseca JA, Gibson PG, Heaney LG, Huang EW, Iwanaga T, Jackson DJ, Koh MS, Lehtimäki L, Máspero J, Mahboub B, Menzies-Gow AN, Mitchell PD, Papadopoulos NG, Papaioannou AI, Perez-de-Llano L, Perng DW, Pfeffer PE, Popov TA, Porsbjerg CM, Rhee CK, Roche N, Sadatsafavi M, Salvi S, Schmid JM, Sheu CC, Sirena C, Torres-Duque CA, Salameh L, Patel PH, Ulrik CS, Wang E, Wechsler ME, Price DB; ISAR LUMINANT Working Group. Real-world biologics response and super-response in the International Severe Asthma Registry cohort. Allergy. 2024 Oct;79(10):2700-2716.

10. Scelo G, Tran TN, Le TT, Fagerås M, Dorscheid D, Busby J, Al-Ahmad M, Al-Lehebi R, Altraja A, Beastall A, Bergeron C, Bjermer L, Bjerrum AS, Cano-Rosales DJ, Canonica GW, Carter V, Charriot J, Christoff GC, Cosio BG, Denton E, Fernandez-Sanchez MJ, Fonseca JA, Gibson PG, Goh C, Heaney LG, Heffler E, Hew M, Iwanaga T, Katial R, Koh MS, Kuna P, Larenas-Linnemann D, Lehtimäki L, Mahboub B, Martin N, Matsumoto H, Menzies-Gow AN, Papadopoulos NG, Patel P, Perez-De-Llano L, Peters M, Pfeffer PE, Popov TA, Porsbjerg CM, Rhee CK, Sadatsafavi M, Taillé C, Torres-Duque CA, Tsai MJ, Ulrik CS, Upham JW, von Bülow A, Wang E, Wechsler ME, Price DB. Exploring Definitions and Predictors of Response to Biologics for Severe Asthma. J Allergy Clin Immunol Pract. 2024 Sep;12(9):2347-2361. 

Jul 23, 2025: Exploring Australian Health Data: OPCRDA Now Summarized in B.R.I.D.G.E. TO DATA®

OPCRDA collects de-identified Electronic Medical Records (EMR) patient data from GP practices and respiratory and allergy specialist practices across Australia. Data include information on prescriptions, medical devices, procedures, clinical measurements, healthcare provider details, biomarker data, patient-reported outcomes, lifestyle factors, and sociodemographic information.

Optimum Patient Care Research Database Australia (OPCRDA) (Australia)

Database Contact Data

Optimum Patient Care Australia Pty Ltd (OPCA)
320 Adelaide Street
Brisbane City, Level 10, Office 1
AUSTRALIA
Email: info@optimumpatientcare.org.au
Phone: (+61) 405 764 842
Fax: (+61) 7 3036 6729

Alternate Contact

Complete the Contact Us form at
https://www.optimumpatientcare.org.au/opcrda

References of Studies Using/Describing Database

1. Price D, Jenkins C, Hancock K, Vella R, Heraud F, Le Cheng P, Murray R, Beekman M, Bosnic-Anticevich S, Botini F, Carter V, Catanzariti A, Doan J, Fletton K, Kichkin A, Le T, Le Lievre C, Lau CM, Novic D, Pakos J, Ranasinghe K, Roussos A, Samuel-King J, Sharma A, Stewart D, Willet B, Bateman E; OPCA Improving Asthma Outcomes in Australia Research Group. The Association Between Short-Acting β2-Agonist Over-Prescription, and Patient-Reported Acquisition and Use on Asthma Control and Exacerbations: Data from Australia. Adv Ther. 2024 Mar;41(3):1262-1283.

2. Hancock KL, Bosnic-Anticevich S, Blakey JD, Hew M, Chung LP, Cvetkovski B, Claxton S, Del Fante P, Denton E, Doan J, Ranasinghe K, Morgan L, Sharma A, Smith PK, Stewart D, Thompson PJ, Wiseman R, Upham JW, Yan KY, Carter V, Dhillon K, Heraud F, Le T, Vella R, Price D; OPCA Improving Asthma outcomes in Australia Research Group. Characterisation of the Australian Adult Population Living with Asthma: Severe - Exacerbation Frequency, Long-Term OCS Use and Adverse Effects. Pragmat Obs Res. 2022 Jul 5;13:43-58.

3. Bateman ED, Price DB, Wang HC, Khattab A, Schonffeldt P, Catanzariti A, van der Valk RJP, Beekman MJHI. Short-acting β2-agonist prescriptions are associated with poor clinical outcomes of asthma: the multi-country, cross-sectional SABINA III study. Eur Respir J. 2022 May 5;59(5):2101402.

4. Evans A, Soremekun S, Stanley B, Appiagyei F, Couper A, Taylor O, Le T, Pullen R, Jones S, Carter V, Price C. Strategies that promote sustainability in quality improvement activities for chronic disease management in healthcare settings: a practical perspective. Quality in Primary Care. 2020;28(6), 55–60. 

Jul 15, 2025: New Longitudinal Population Database added from the UK

The Optimum Patient Care Research Database (OPCRD) provides de-identified data from ~1,100 general practices and more than 25 million patients in the UK. The de-identified electronic medical records, patient questionnaires and clinical review data provided by OPCRD offer an essential source of real-world data to promote evidence-based research and quality improvement.

Optimum Patient Care Research Database (OPCRD) (United Kingdom)

Database Contact Data

OPCRD
5 Coles Lane
Oakington, CB24 3BA
UNITED KINGDOM
Email: info@optimumpatientcare.org
Phone: (+44) 1223 967855

Alternate Contact

You may also contact OPCRD via their contact form at https://opcrd.optimumpatientcare.org/contact-us

References of Studies Using/Describing Database

1. Kaplan A, Heatley H, Townend J, Skinner D, Carter V, Hubbard R, Lee TT, Koh MS, Price D. The Real-World Impact of Glucagon-Like Peptide 1 Receptor Agonists on Asthma Control in People with High-Risk Asthma and Obesity. Adv Ther. 2025 Jun;42(6):2950-2956.

2. Sadatsafavi M, Tran TN, Scelo G, Tsai MJ, Busby J, Emmanuel B, Heaney LG, Jenkins C, Hoyte F, Canonica GW, Katial R, Heffler E, Wang E, Puggioni F, Wechsler ME, Ardusso LRF, Máspero J, Sivori M, Emmas C, Menzies-Gow AN, Stjepanovic N, Bosnic-Anticevich SZ, Cochrane B, Denton E, Gibson PG, Hew M, Middleton PG, Peters MJ, Brusselle GG, Louis R, Schleich F, Christoff GC, Popov TA, Bergeron C, Bhutani M, Chapman KR, Côté A, Couillard S, Dorscheid DR, Jiménez-Maldonado L, Solarte I, Torres-Duque CA, Hansen S, Porsbjerg CM, Ulrik CS, Altraja A, Bourdin A, Exarchos KP, Gogali A, Kostikas K, Makris MP, Papaioannou AI, Mitchell PD, Iwanaga T, Nagano T, Tohda Y, Al-Ahmad MS, Larenas-Linnemann D, Aarli BB, Kuna P, Chaves Loureiro C, Al-Lehebi R, Bulkhi AA, Chen W, Juang YR, Koh MS, Liu A, Rhee CK, Cosio BG, Perez-de-Llano L, Perng DW, Sheu CC, Wang HC, Mahboub B, Salameh L, Jackson DJ, Patel PH, Pfeffer PE, Lugogo N, Pleasants RA, Beastall A, Bulathsinhala L, Carter V, Eleangovan N, Fletton K, Townend J, Murray RB, Price DB. Prevention of Cardiovascular and Other Systemic Adverse Outcomes in Patients with Asthma Treated with Biologics. Am J Respir Crit Care Med. 2025 May 18. Epub ahead of print. 

3. Chen W, Tran TN, Townend J, Christoff GC, Tsai MJ, Altraja A, Cochrane B, Cosio BG, Sivori M, Murray RB, Makris MP, Scelo G, Bulathsinhala L, Ardusso LRF, Franchi ME, Máspero J, Saldarini F, Stok AM, Tomaszuk AG, Yañez A, Emmanuel B, Emmas C, Kostikas K, Menzies-Gow AN, Stjepanovic N, Bosnic-Anticevich SZ, Denton E, Gibson PG, Hew M, Jenkins C, Middleton PG, Peters MJ, Upham JW, Brusselle GG, Louis R, Schleich F, Pitrez PM, Popov TA, Bergeron C, Bhutani M, Chapman KR, Côté A, Couillard S, Dorscheid DR, Lougheed MD, Sadatsafavi M, Celis-Preciado CA, Jiménez-Maldonado L, Rodríguez-Cáceres B, Cano Rosales DJ, Solarte I, Torres-Duque CA, Hansen S, Porsbjerg CM, Ulrik CS, Bourdin A, Bakakos P, Exarchos KP, Gogali A, Ladias AA, Papadopoulos NG, Papaioannou AI, Costello RW, Cushen B, Mitchell PD, Canonica GW, Heffler E, Puggioni F, Iwanaga T, Nagano T, Tohda Y, Al-Ahmad MS, Larenas-Linnemann D, Aarli BB, Lehmann S, Kuna P, Ferreira JA, Fonseca JA, Loureiro CC, Al-Lehebi R, Bulkhi AA, Juang YR, Koh MS, Liu A, Rhee CK, Perez-de-Llano L, Fu PK, Perng DW, Sheu CC, Wang HC, Mahboub B, Salameh L, Busby J, Heaney LG, Jackson DJ, Patel PH, Pfeffer PE, Hoyte F, Katial RK, Lugogo N, Pleasants RA, Wang E, Wechsler ME, Beastall A, Carter V, Eleangovan N, Fletton K, Price DB; ISAR SOLAR I Working Group. Impact of Biologics Initiation on Oral Corticosteroid Use in the International Severe Asthma Registry and the Optimum Patient Care Research Database: A Pooled Analysis of Real-World Data. J Allergy Clin Immunol Pract. 2025 Apr 26:S2213-2198(25)00390-3. doi: 10.1016/j.jaip.2025.04.032. Epub ahead of print. 

4. Gonnelli F, Eleangovan N, Smith U, Heatley H, Navarantam V, Corte TJ, Price DB, Carter V, Bonifazi M, Fermoyle CC, Hubbard R. Incidence and survival of interstitial lung diseases in the UK in 2010-2019. ERJ Open Res. 2025 Mar 3;11(2):00823-2024.

5. Lynam A, Curtis C, Stanley B, Heatley H, Worthington C, Roberts EJ, Price C, Carter V, Dennis J, McGovern A, Price D. Data-Resource Profile: United Kingdom Optimum Patient Care Research Database. Pragmat Obs Res. 2023 Apr 27;14:39-49.

6. Loewenthal L, Busby J, McDowell R, Brown T, Burhan H, Chaudhuri R, Dennison P, Dodd JW, Doe S, Faruqi S, Gore R, Idris E, Jackson DJ, Patel M, Pantin T, Pavord I, Pfeffer PE, Price DB, Rupani H, Siddiqui S, Heaney LG, Menzies-Gow A; UK Severe Asthma Registry. Impact of sex on severe asthma: a cross-sectional retrospective analysis of UK primary and specialist care. Thorax. 2024 Apr 15;79(5):403-411.

7. Tran TN, Heatley H, Rowell J, Chan JSK, Bourdin A, Chapaneri J, Emmanuel B, Gibson D, Jackson DJ, Menzies-Gow AN, Murray R, Skinner D, Price DB. Longitudinal patterns of intermittent oral corticosteroid therapy for asthma in the United Kingdom. J Allergy Clin Immunol Glob. 2024 Feb 2;3(2):100225.

8. Horne EMF, McLean S, Alsallakh MA, Davies GA, Price DB, Sheikh A, Tsanas A. Defining clinical subtypes of adult asthma using electronic health records: Analysis of a large UK primary care database with external validation. Int J Med Inform. 2023 Feb;170:104942.

9. Ryan D, Heatley H, Heaney LG, Jackson DJ, Pfeffer PE, Busby J, Menzies-Gow AN, Jones R, Tran TN, Al-Ahmad M, Backer V, Belhassen M, Bosnic-Anticevich S, Bourdin A, Bulathsinhala L, Carter V, Chaudhry I, Eleangovan N, FitzGerald JM, Gibson PG, Hosseini N, Kaplan A, Murray RB, Rhee CK, Van Ganse E, Price DB. Potential Severe Asthma Hidden in UK Primary Care. J Allergy Clin Immunol Pract. 2021 Apr;9(4):1612-1623.e9. doi: 10.1016/j.jaip.2020.11.053. Epub 2020 Dec 9. Erratum in: J Allergy Clin Immunol Pract. 2021 Nov;9(11):4182.

10. Magnussen H, Lucas S, Lapperre T, Quint JK, Dandurand RJ, Roche N, Papi A, Price D, Miravitlles M; Respiratory Effectiveness Group (REG). Withdrawal of inhaled corticosteroids versus continuation of triple therapy in patients with COPD in real life: observational comparative effectiveness study. Respir Res. 2021 Jan 21;22(1):25.

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